CHANGES IN BRAIN ENERGY AND PHOSPHOLIPID-METABOLISM DURING DEVELOPMENT AND AGING IN THE FISCHER-344 RAT

被引：72

作者：

PETTEGREW, JW

PANCHALINGAM, K

WITHERS, G

MCKEAG, D

STRYCHOR, S

机构：

[1] Laboratory of Neurophysics, Department of Psychiatry and Neurology, University of Pittsburgh, Pittsburgh, PA

来源：

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 1990年 / 49卷 / 03期

关键词：

!sup]31[!/sup]P Nuclear magnetic resonance; Aging; Brain development; Phospholipid;

D O I：

10.1097/00005072-199005000-00005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effects of brain development and aging on high-energy phosphate and membrane phospholipid metabolism were studied from birth to senescence in the Fischer 344 rat using 3, P nuclear magnetic resonance spectroscopy. Marked developmental and smaller aging-related changes were observed in brain high-energy phosphates, phospholipid precursors and phospholipid breakdown products. The biochemical changes correlate with known histological and electrophysiological changes occurring in the brain during development (neuritic sprouting and onset of brain electrical activity) and aging (loss of dendritic processes). These findings provide a framework for interpreting the effects of physiological insults during different developmental and aging periods. © 1990 by the American Association of Neuropathologists.

引用

页码：237 / 249

页数：13

共 35 条

[1] BARANY M, 1982, METHOD ENZYMOL, V85, P624
[2] BARRIONUEVO G, 1988, Neurology, V38, P336
[3] NEURONAL DEATH IN THE DEVELOPMENT OF THE VERTEBRATE NERVOUS-SYSTEM
CLARKE, PGH
[J]. TRENDS IN NEUROSCIENCES, 1985, 8 (08) : 345 - 349
[4] ACID SOLUBLE PHOSPHATES IN DEVELOPING RABBIT BRAIN
COHEN, MM
LIN, S
[J]. JOURNAL OF NEUROCHEMISTRY, 1962, 9 (JUL) : 345 - &
[5] P-31 NUCLEAR MAGNETIC-RESONANCE ANALYSIS OF BRAIN - NORMOXIC AND ANOXIC BRAIN-SLICES
COHEN, MM
PETTEGREW, JW
KOPP, SJ
MINSHEW, N
GLONEK, T
[J]. NEUROCHEMICAL RESEARCH, 1984, 9 (06) : 785 - 801
[6] A GOLGI-STUDY OF THE SUPERFICIAL PYRAMIDAL CELLS IN THE SOMATOSENSORY CORTEX OF SOCIALLY REARED OLD ADULT-RATS
CONNOR, JR
BEBAN, SE
HOPPER, PA
HANSEN, B
DIAMOND, MC
[J]. EXPERIMENTAL NEUROLOGY, 1982, 76 (01) : 35 - 45
[7] OCCIPITAL CORTICAL MORPHOLOGY OF THE RAT - ALTERATIONS WITH AGE AND ENVIRONMENT
CONNOR, JR
DIAMOND, MC
JOHNSON, RE
[J]. EXPERIMENTAL NEUROLOGY, 1980, 68 (01) : 158 - 170
[8] REGRESSIVE EVENTS IN NEUROGENESIS
COWAN, WM
FAWCETT, JW
OLEARY, DDM
STANFIELD, BB
[J]. SCIENCE, 1984, 225 (4668) : 1258 - 1265
[9] METABOLISM OF RAT BRAIN MITOCHONDRIA DURING POSTNATAL DEVELOPMENT
DAHL, DR
SAMSON, FE
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1959, 196 (02): : 470 - 472
[10] CARBOHYDRATE AND ENERGY METABOLISM IN PERINATAL RAT-BRAIN - RELATION TO SURVIVAL IN ANOXIA
DUFFY, TE
KOHLE, SJ
VANNUCCI, RC
[J]. JOURNAL OF NEUROCHEMISTRY, 1975, 24 (02) : 271 - 276

← 1 2 3 4 →