THE ACTH/MSH(4-9) ANALOG ORG2766 IMPROVES RETRIEVAL OF INFORMATION AFTER A FIMBRIA FORNIX TRANSECTION

被引：24

作者：

PITSIKAS, N

SPRUIJT, BM

ALGERI, S

GISPEN, WH

机构：

[1] STATE UNIV UTRECHT, INST MOLEC BIOL & MED BIOTECHNOL, RUDOLF MAGNUS INST, 3584 CH UTRECHT, NETHERLANDS

[2] INST RIC FARMACOL, I-20157 MILAN, ITALY

来源：

PEPTIDES | 1990年 / 11卷 / 05期

关键词：

Avoidance; Fimbria fornix; Org2766; Retrieval; Spatial orientation;

D O I：

10.1016/0196-9781(90)90008-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fimbria fornix of male Wistar rats was transected unilaterally after they had been successfully trained in the Morris maze and the passive avoidance task. Sham-operated and lesioned animals were treated either with Org2766 or saline for two weeks. Subsequently, the performance of all groups was tested again starting two days after the last treatment. The lesioned animals showed a deficit in performance in both tasks, indicating interference of the lesion with retrieval of information. Org2766 improved the poor performance of the lesioned animals in the Morris maze, but not in the passive avoidance task. © 1990.

引用

页码：911 / 914

页数：4

共 23 条

[1] RETENTION OF A PASSIVE AVOIDANCE RESPONSE AS A FUNCTION OF INTENSITY AND DURATION OF ELECTRIC SHOCK [J].