A SIMPLE FLOW-LIMITED MODEL FOR EXCHANGE OF ORGANIC-CHEMICALS AT FISH GILLS

被引:46
作者
ERICKSON, RJ
MCKIM, JM
机构
[1] U.S. Environmental Protection Agency, Environmental Research Laboratory-Duluth, Duluth, Minnesota
关键词
Gill exchange; Organic chemicals; Rainbow trout; Toxicokinetic model;
D O I
10.1002/etc.5620090205
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
A mathematical model for the exchange of organic chemicals by fish gills was formulated based solely on the limitations imposed by the flows of water and blood into the gills. For large rainbow trout, this model was found to closely follow the magnitude and trends of observed gill uptake rates over a range of octanol/water partition coefficient from 1 to 106. Observations averaged only about 30% less than model predictions. This modest lack‐of‐fit is presumably due to the effects of diffusional barriers and ionization which would further limit uptake, although uncertainties in model parameters and data are likely also partly responsible. This analysis suggests that these basic physiological parameters are of major importance in the regulation of exchange at fish gills and should be accounted for in more detailed toxicokinetic models. Also, this simple model could by itself be useful for approximate assessments of accumulation of organic chemicals by fish. Copyright © 1990 SETAC
引用
收藏
页码:159 / 165
页数:7
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