TRENDS IN NMR-STUDIES OF PARAMAGNETIC GD(III) COMPLEXES AS POTENTIAL CONTRAST AGENTS IN MRI

被引：23

作者：

AIME, S

BARBERO, L

BOTTA, M

机构：

[1] Dipartimento di Chimica Fisica, Chimica Inorganica e Chimica dei Materiali, Torino

来源：

MAGNETIC RESONANCE IMAGING | 1991年 / 9卷 / 05期

关键词：

PARAMAGNETIC GD(III) COMPLEXES; MICELLES; NONCOVALENT INTERACTION;

D O I：

10.1016/0730-725X(91)90386-Z

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The paramagnetic Gd(III) complexes with polyaminocarboxylate ligands are intensively studied as possible Contrast Agents for Magnetic Resonance Imaging (M.R.I.). Their ability to enhance the solvent proton relaxation rate is mainly determined by the molecular reorientational time (tau(R)). In order to increase tau(R) we studied the formation of non-covalent interactions between functionalized Gd(III)-complexes and micelles. The N.M.R.D. (Nuclear Magnetic Relaxation Dispersion) profiles of aqueous solutions of these paramagnetic complexes with hexadecyltrimethylammonium bromide (CTABr) were measured and the results could be accounted for by difference in negative charge and number of hydrophobic aromatic residues among the different complexes.

引用

页码：843 / 847

页数：5

共 12 条

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