ANTIOXIDANT FUNCTION OF FUNGAL MELANIN

被引：150

作者：

JACOBSON, ES

TINNELL, SB

机构：

[1] VIRGINIA COMMONWEALTH UNIV,DEPT MED,RICHMOND,VA 23298

[2] VIRGINIA COMMONWEALTH UNIV,DEPT MICROBIOL & IMMUNOL,RICHMOND,VA 23298

来源：

JOURNAL OF BACTERIOLOGY | 1993年 / 175卷 / 21期

关键词：

D O I：

10.1128/jb.175.21.7102-7104.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Polyphenols have been implicated in the virulence and oxidant resistance of Cryptococcus neoformans. Although monomeric polyphenols did not protect against the prooxidant, plumbagin, polymeric dopamine-melanin melanin conferred resistance both to hypochlorite and to permanganate. The physiologic antioxidant capacity conferred by melanin was found to be 21.3 x 10(-15) mole-equivalents per cell, a value which approximates oxidant production by stimulated macrophages.

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收藏

页码：7102 / 7104

页数：3

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