NONANTIGEN SIGNALS FOR B-CELL GROWTH AND DIFFERENTIATION TO ANTIBODY SECRETION

被引：21

作者：

LEDERMAN, S ^{[1
]}

YELLIN, MJ ^{[1
]}

COVEY, LR ^{[1
]}

CLEARY, AM ^{[1
]}

CALLARD, R ^{[1
]}

CHESS, L ^{[1
]}

机构：

[1] UNIV LONDON,INST CHILD HLTH,LONDON WC1N 1EH,ENGLAND

来源：

CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 03期

关键词：

D O I：

10.1016/0952-7915(93)90066-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recently, significant progress had been made in understanding the T-B lymphocyte interactions that control humoral immunity. This review highlights experiments that demonstrate a central role for interactions between T-cell-B-cell-activating molecule (CD40 ligand) expressed on T cells and CD40 on B cells in B-cell activation and immunoglobulin isotype switching, both in vitro and in vivo.

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收藏

页码：439 / 444

页数：6

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