ANTHROTAININ, AN INHIBITOR OF SUBSTANCE-P BINDING PRODUCED BY GLIOCLADIUM-CATENULATUM

被引：16

作者：

WONG, SM ^{[1
]}

KULLNIG, R ^{[1
]}

DEDINAS, J ^{[1
]}

APPELL, KC ^{[1
]}

KYDD, GC ^{[1
]}

GILLUM, AM ^{[1
]}

COOPER, R ^{[1
]}

MOORE, R ^{[1
]}

机构：

[1] EASTMAN KODAK CO,DIV ANALYT TECHNOL,ROCHESTER,NY 14650

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 02期

关键词：

D O I：

10.7164/antibiotics.46.214

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Substance P (SP) is an undecapeptide belonging to a family of chemically related neurotransmitters and neuromodulators known as neurokinins. In our search for SP antagonists, we screened microbial broth extracts for the ability to inhibit radiolabeled SP binding to membranes prepared from rat forebrain. Anthrotainin was isolated from a fungal culture and determined to be a novel tetracyclic compound, with an IC50 of 3 muM against [I-125]SP. The structure, spectroscopic, chemical, and pharmacological properties of anthrotainin are presented.

引用

页码：214 / 221

页数：8

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