CELL-MEMBRANE DYNAMICS AND INSULIN-RESISTANCE IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS

被引：61

作者：

TONG, P ^{[1
]}

THOMAS, T ^{[1
]}

BERRISH, T ^{[1
]}

HUMPHRISS, D ^{[1
]}

BARRIOCANAL, L ^{[1
]}

STEWART, M ^{[1
]}

WALKER, M ^{[1
]}

WILKINSON, R ^{[1
]}

ALBERTI, KGMM ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE,SCH MED,DEPT MED,SUBDEPT NEPHROL,NEWCASTLE TYNE NE2 4HH,TYNE & WEAR,ENGLAND

来源：

LANCET | 1995年 / 345卷 / 8946期

关键词：

D O I：

10.1016/S0140-6736(95)90343-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin resistance in non-insulin-dependent diabetes mellitus (NIDDM) could be ralated to changes in cell membrane properties. We measured insulin sensitivity and mononuclear leucocyte membrane fluidity by fluorescence polarisation in fifteen NIDDM patients and twenty-one normal subjects. Core-region anisotropy was significantly lower in leucocytes from diabetic subjects (mean 0.164 vs 0.174, p<0.001). Insulin sensitivity was positively correlated with such anisotropy before and after acute invitro insulin treatment. There was no difference in superficial membrane anisotropy. This study suggests that altered membrane dynamics in NIDDM may contribute to insulin resistance.

引用

页码：357 / 358

页数：2

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