The Effects of Topical Agent (Kelo-Cote or Contractubex) Massage on the Thickness of Post-Burn Scar Tissue Formed in Rats

被引：16

作者：

Ko, Won Jin ^{[1
]}

Na, Young Cheon ^{[1
]}

Suh, Bum Sin ^{[1
]}

Kim, Hyeon A. ^{[1
]}

Heo, Woo Hoe ^{[1
]}

Choi, Gum Ha ^{[2
]}

Lee, Seo Ul ^{[3
]}

机构：

[1] Wonkwang Univ, Wonkwang Univ Hosp, Sch Med, Dept Plast & Reconstruct Surg, Iksan, South Korea

[2] Wonkwang Univ, Wonkwang Univ Hosp, Sch Med, Dept Pathol, Iksan, South Korea

[3] Wonkwang Inst Clin Med, Iksan, South Korea

来源：

ARCHIVES OF PLASTIC SURGERY-APS | 2013年 / 40卷 / 06期

关键词：

Burns; Cicatrix; hypertrophic; Wound healing; Massage;

D O I：

10.5999/aps.2013.40.6.697

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background We conducted an experimental study to compare the effect of massage using topical agents (Kelo-cote or Contractubex) on scar formation by massaging the healed burn wound on the dorsal area of Sprague-Dawley (SD) rats. Methods Four areas of second degree contact burn were made on the dorsal area of each of 15 SD rats, using a soldering iron 15 mm in diameter. After gross epithelialization in the defect, 15 SD rats were randomly divided into four groups: the Kelo-cote group, Contractubex group, Vaseline group, and control group. Rats in three of the groups (all but the Control group) were massaged twice per day for 5 minutes each day, while those in the Control group were left unattended. For histologic analysis, we performed a biopsy and evaluated the thickness of scar tissue. Results In the Kelo-cote and Contractubex groups, scar tissue thicknesses showed a significant decrease, compared with the Vaseline and control groups. However, no significant differences were observed between the Kelo-cote and Contractubex groups. In the Vaseline group, scar tissue thicknesses showed a significant decrease, compared with the control groups. Conclusions The findings of this study suggest that massage using a topical agent is helpful in the prevention of scar formation and that massage only with lubricant (no use of a topical agent) also has a considerable effect, although not as much as the use of a topical agent. Thus, we recommend massage with a topical agent on the post-burn scar as an effective method for decreasing the scar thickness.

引用

页码：697 / 704

页数：8

共 24 条

[1]

Broughton II G., Janis J.E., Atinger C.E., Te basic science of wound healing, Plast Reconstr Surg, 117, (2006)

[2]

Singer A.J., Clark R.A., Cutaneous wound healing, N Engl J Med, 341, pp. 738-746, (1999)

[3]

Desmouliere A., Redard M., Darby I., Et al., Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar, Am J Pathol, 146, pp. 56-66, (1995)

[4]

Gurtner G.C., Werner S., Barrandon Y., Et al., Wound repair and regeneration, Nature, 453, pp. 314-321, (2008)

[5]

Alster T.S., Tanzi E.L., Hypertrophic scars and keloids: Etiology and management, Am J Clin Dermatol, 4, pp. 235-243, (2003)

[6]

Berman B., Perez O.A., Konda S., Et al., A review of the biologic effects, clinical efficacy, and safety of silicone elastomer sheeting for hypertrophic and keloid scar treatment and management, Dermatol Surg, 33, pp. 1291-1302, (2007)

[7]

Niessen F.B., Spauwen P.H., Schalkwijk J., Et al., On the nature of hypertrophic scars and keloids: A review, Plast Reconstr Surg, 104, pp. 1435-1458, (1999)

[8]

de Giorgi V., Sestini S., Mannone F., Et al., Te use of silicone gel in the treatment of fresh surgical scars: A randomized study, Clin Exp Dermatol, 34, pp. 688-693, (2009)

[9]

Gold M.H., Foster T.D., Adair M.A., Et al., Prevention of hyper-trophic scars and keloids by the prophylactic use of topical silicone gel sheets following a surgical procedure in an ofce seting, Dermatol Surg, 27, pp. 641-644, (2001)

[10]

Momeni M., Hafezi F., Rahbar H., Et al., Effects of silicone gel on burn scars, Burns, 35, pp. 70-74, (2009)

← 1 2 3 →