IMIDAZO[1,5-A]PYRIDINES - A NEW CLASS OF THROMBOXANE-A2 SYNTHETASE INHIBITORS

被引：113

作者：

FORD, NF ^{[1
]}

BROWNE, LJ ^{[1
]}

CAMPBELL, T ^{[1
]}

GEMENDEN, C ^{[1
]}

GOLDSTEIN, R ^{[1
]}

GUDE, C ^{[1
]}

WASLEY, JWF ^{[1
]}

机构：

[1] CIBA GEIGY CORP, DIV PHARMACEUT, RES DEPT, SUMMIT, NJ 07901 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1985年 / 28卷 / 02期

关键词：

D O I：

10.1021/jm00380a003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：164 / 170

页数：7

共 27 条

[1] A DIRECT METHOD FOR THE SUBSTITUTION OF IMIDAZO[1,5-A]PYRIDINES AT POSITION-5 [J].

BLATCHER, P ;

MIDDLEMISS, D .

TETRAHEDRON LETTERS, 1980, 21 (22) :2195-2196

[2] HETEROCYCLIC SYSTEMS RELATED TO PYRROCOLINE .1. 2-3A-DIAZAINDENE [J].

BOWER, JD ;

RAMAGE, GR .

JOURNAL OF THE CHEMICAL SOCIETY, 1955, :2834-2837

[3]

CASEY LC, 1981, CIRC SHOCK, V8, P233

[4]

CASEY LC, 1982, J PHARMACOL EXP THER, V222, P441

[5] IONIZATION-CONSTANTS BY CURVE FITTING - APPLICATION TO THE DETERMINATION OF PARTITION-COEFFICIENTS [J].

CLARKE, FH .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1984, 73 (02) :226-230

[6] ARTERIAL-WALLS ARE PROTECTED AGAINST DEPOSITION OF PLATELET THROMBI BY A SUBSTANCE (PROSTAGLANDIN-X) WHICH THEY MAKE FROM PROSTAGLANDIN ENDOPEROXIDES [J].

GRYGLEWSKI, RJ ;

BUNTING, S ;

MONCADA, S ;

FLOWER, RJ ;

VANE, JR .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 1976, 12 (05) :685-713

[7] THROMBOXANES AND PROSTACYCLIN - POSITIVE AND NEGATIVE MODULATORS OF TUMOR-GROWTH [J].

HONN, KV ;

MEYER, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1981, 102 (04) :1122-1129

[8] HIGHLY SELECTIVE INHIBITORS OF THROMBOXANE SYNTHETASE .1. IMIDAZOLE DERIVATIVES [J].

IIZUKA, K ;

AKAHANE, K ;

MOMOSE, DI ;

NAKAZAWA, M ;

TANOUCHI, T ;

KAWAMURA, M ;

OHYAMA, I ;

KAJIWARA, I ;

IGUCHI, Y ;

OKADA, T ;

TANIGUCHI, K ;

MIYAMOTO, T ;

HAYASHI, M .

JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (10) :1139-1148

[9] CHARACTERIZATION OF IMIDAZO[1,5-A]PYRIDINE-5-HEXANOIC ACID (CGS-13080) AS A SELECTIVE THROMBOXANE SYNTHETASE INHIBITOR USING INVITRO AND INVIVO BIOCHEMICAL-MODELS [J].

KU, EC ;

MCPHERSON, SE ;

SIGNOR, C ;

CHERTOCK, H ;

CASH, WD .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 112 (03) :899-906

[10] RECEPTOR-BASED DESIGN OF DIHYDROFOLATE-REDUCTASE INHIBITORS - COMPARISON OF CRYSTALLOGRAPHICALLY DETERMINED ENZYME BINDING WITH ENZYME AFFINITY IN A SERIES OF CARBOXY-SUBSTITUTED TRIMETHOPRIM ANALOGS [J].

KUYPER, LF ;

ROTH, B ;

BACCANARI, DP ;

FERONE, R ;

BEDDELL, CR ;

CHAMPNESS, JN ;

STAMMERS, DK ;

DANN, JG ;

NORRINGTON, FEA ;

BAKER, DJ ;

GOODFORD, PJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (10) :1120-1122

← 1 2 3 →