PLASMA AMINO-ACID-CONCENTRATIONS IN HEALTHY ELDERLY MEN AND WOMEN

被引：61

作者：

CABALLERO, B ^{[1
]}

GLEASON, RE ^{[1
]}

WURTMAN, RJ ^{[1
]}

机构：

[1] MIT,CLIN RES CTR,CAMBRIDGE,MA 02139

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1991年 / 53卷 / 05期

关键词：

PLASMA AMINO ACIDS; AGING; NORMAL VALUES;

D O I：

10.1093/ajcn/53.5.1249

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Postabsorptive plasma concentrations of the large neutral amino acids (LNAAs) were measured in 74 elderly (age 71 +/- 8 y) and 138 young (age 26 +/- 5 y) healthy subjects. Plasma concentrations of valine, leucine, and isoleucine were significantly lower in young females than in young males. This gender-related difference was not observed among elderly subjects because aging was associated with a significant rise in plasma LNAAs in females but not in males. Multiple-regression analysis of plasma amino acid concentrations from female subjects revealed a significant and positive effect of age on plasma valine, leucine, isoleucine, phenylalanine, and tyrosine but not on plasma tryptophan or methionine. Tryptophan was the only amino acid to exhibit a significant response to age in males, consisting of a 14% decline in the elderly subjects. Percentile ranges are presented for young and elderly females and males for each of the amino acids.

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页码：1249 / 1252

页数：4

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