BROMOBENZOFURANS - A NEW CLASS OF POTENT, NONPEPTIDE ANTAGONISTS OF ANGIOTENSIN-II

被引：58

作者：

MIDDLEMISS, D

DREW, GM

ROSS, BC

ROBERTSON, MJ

SCOPES, DIC

DOWLE, MD

AKERS, J

CARDWELL, K

CLARK, KL

COOTE, S

ELDRED, CD

HAMBLETT, J

HILDITCH, A

HIRST, GC

JACK, T

MONTANA, J

PANCHAL, TA

PATON, JMS

SHAH, P

STUART, G

TRAVERS, A

机构：

[1] Glaxo Group Research, Ware

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)81053-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This paper describes the synthesis and pharmacology of a novel series of benzofurans which are antagonists of angiotensin II. One of these, the bromobenzofuran 11b, is a potent (apparent pK(B) = 9.8) and specific antagonist angiotensin II which, after oral administration (10mg/Kg), causes marked and long-lasting (> 24h) falls in blood pressure in renal hypertensive rats.

引用

收藏

页码：711 / 716

页数：6

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