EFFECTS OF GLUCAGON AND ALPHA-AGONISTS AND BETA-AGONISTS ON GLYCOGENOLYSIS AND GLUCONEOGENESIS IN ISOLATED OVINE HEPATOCYTES

被引：18

作者：

FAULKNER, A

POLLOCK, HT

机构：

[1] Hannah Research Institute, Ayr

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1052卷 / 01期

关键词：

(Ovine hepatocyte); Adrenergic agonist; Glucagon; Gluconoegenesis; Glycogenolysis; Isoproterenol; Phenylephrine;

D O I：

10.1016/0167-4889(90)90081-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(1) The effects of glucagon, dibutyryl cyclic AMP, vasopressin, phenylelphrine, and isoproterenol on glycogenolysis and gluconeogenesis were investigated using isolated ovine hepatocytes. (2) Glycogenolysis was stimulated by all effectors except vasopressin. The response to α-agonists was greater than that of β-agonists in older animals. Stimulation by β-agonists increased after 30 h primary culture. (3) Glucoeneogenesis from propionate or l-lactate plus pyruvate was stimulated to a small extent by dibutyryl cyclic AMP, glucagon and isoproterenol but not by vasopressin or phenylephrine. (4) No effects of lactation were observed. (5) Data are compared to results obtained in other species and the physiological significance of the results in relation to the ruminant is discussed. © 1990.

引用

页码：229 / 234

页数：6

共 44 条

[1] ADRENERGIC REGULATION OF GLYCOGENOLYSIS IN ISOLATED GUINEA-PIG HEPATOCYTES - EVIDENCE THAT BETA-2-RECEPTORS MEDIATE CATECHOLAMINE STIMULATION OF GLYCOGENOLYSIS [J].