DETERMINATION OF ZOLPIDEM AND ZOPICLONE IN SERUM BY CAPILLARY COLUMN GAS-CHROMATOGRAPHY

被引：28

作者：

DEBRUYNE, D ^{[1
]}

LACOTTE, J ^{[1
]}

DELIGNY, BH ^{[1
]}

MOULIN, M ^{[1
]}

机构：

[1] UNIV CAEN,DIV NEPHROL,F-14032 CAEN,FRANCE

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1991年 / 80卷 / 01期

关键词：

D O I：

10.1002/jps.2600800118

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A gas chromatographic method using a short, high-resolution capillary column connected to a specific thermoionic detector and requiring a simple and short extraction step without evaporation was developed for the rapid and precise determination of two new hypnotics, zolpidem and zopiclone, in serum at concentrations > 5ng/mL. The assay was linear between 5 and 200 ng/mL, with coefficients of the intra- and interassay variation < 5% for both. The method was validated and then used to analyze zolpidem serum concentrations in nine rabbits after oral administration of 0.5 mg/kg and zopiclone serum concentration in six patients treated orally with a 7.5-g dose.

引用

页码：71 / 74

页数：4

共 16 条

[1] HIGH-AFFINITY [H-3] ZOLPIDEM BINDING IN THE RAT-BRAIN - AN IMIDAZOPYRIDINE WITH AGONIST PROPERTIES AT CENTRAL BENZODIAZEPINE RECEPTORS [J].