PRESYMPTOMATIC SCREENING FOR MULTIPLE ENDOCRINE NEOPLASIA TYPE-2A WITH LINKED DNA MARKERS

被引：70

作者：

MATHEW, CGP

EASTON, DF

NAKAMURA, Y

PONDER, BAJ

机构：

[1] UNIV CAMBRIDGE,DEPT PATHOL,CANC RES CTR,HUMAN CANC GENET RES GRP,TENNIS COURT RD,CAMBRIDGE CB2 1QP,ENGLAND

[2] INST CANC RES,EPIDEMIOL SECT,SUTTON SM2 5PX,SURREY,ENGLAND

[3] JAPANESE FDN CANC RES,INST CANC,DIV BIOCHEM,TOKYO 170,JAPAN

来源：

LANCET | 1991年 / 337卷 / 8732期

关键词：

D O I：

10.1016/0140-6736(91)93329-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Seven DNA markers from the pericentromeric region of chromosome 10 were tested for linkage to MEN 2A in a panel of 17 families. Four of the markers proved to be tightly linked and therefore suitable for predictive testing. The markers were used to estimate carrier risks for individuals who had a negative biochemical screening test for thyroid C-cell hyperplasia. The analysis substantially altered the carrier risks of most of these individuals, which suggests that typing with DNA markers should be introduced into the screening programme of MEN 2A families. Accurate prenatal diagnosis for this disorder is also now possible.

引用

页码：7 / 11

页数：5

共 26 条

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