INTERACTIONS OF SPIRONOLACTONE WITH (+)-[H-3]-ISRADIPINE AND (-)-[H-3]-DESMETHOXYVERAPAMIL BINDING-SITES IN VASCULAR SMOOTH-MUSCLE

被引：5

作者：

MIRONNEAU, J

SAYET, I

RAKOTOARISOA, L

DACQUET, C

MIRONNEAU, C

机构：

[1] Lab. Physiologie Cellulaire, INSERM Jeune Formation 88-13, Universite de Bordeaux II, 33076 Bordeaux Cedex

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1990年 / 101卷 / 01期

关键词：

D O I：

10.1111/j.1476-5381.1990.tb12077.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Spironolactone partially inhibited the specific binding of (+)-[3H]-isradipine and (-)-[3H]-desmethoxyverapamil to vascular smooth muscle membranes. It is suggested that spironolactone interacts at a binding site of the calcium channel complex and allosterically modulates ligand binding at receptor sites in the channel.

引用

页码：6 / 7

页数：2

共 9 条

[1] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[2] (+)-[H-3]-PN 200-110 BINDING TO CELL-MEMBRANES AND INTACT STRIPS OF PORTAL-VEIN SMOOTH-MUSCLE - CHARACTERIZATION AND MODULATION BY MEMBRANE-POTENTIAL AND DIVALENT-CATIONS
DACQUET, C
LOIRAND, G
RAKOTOARISOA, L
MIRONNEAU, C
MIRONNEAU, J
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1989, 97 (01) : 256 - 262
[3] SPIRONOLACTONE INHIBITION OF CONTRACTION AND CALCIUM CHANNELS IN RAT PORTAL-VEIN
DACQUET, C
LOIRAND, G
MIRONNEAU, C
MIRONNEAU, J
PACAUD, P
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1987, 92 (03) : 535 - 544
[4] SPECIFIC BINDING OF [H-3]LABELED NITRENDIPINE TO MEMBRANES FROM CORONARY-ARTERIES AND HEART IN RELATION TO PHARMACOLOGICAL EFFECTS - PARADOXICAL STIMULATION BY DILTIAZEM
DEPOVER, A
MATLIB, MA
LEE, SW
DUBE, GP
GRUPP, IL
GRUPP, G
SCHWARTZ, A
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 108 (01) : 110 - 117
[5] GODFRAIND T, 1986, PHARMACOL REV, V38, P321
[6] DESMETHOXYVERAPAMIL-SENSITIVE CALCIUM CHANNELS IN RAT PORTAL-VEIN SMOOTH-MUSCLE
LOIRAND, G
DACQUET, C
PACAUD, P
RAKOTOARISOA, L
SAYET, I
MIRONNEAU, C
MIRONNEAU, J
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 167 (02) : 265 - 274
[7] ANALYSIS OF THE PROPERTIES OF BINDING OF CALCIUM-CHANNEL ACTIVATORS AND INHIBITORS TO DIHYDROPYRIDINE RECEPTORS IN CHICK HEART MEMBRANES
MAAN, AC
HOSEY, MM
[J]. CIRCULATION RESEARCH, 1987, 61 (03) : 379 - 388
[8] LIGAND - A VERSATILE COMPUTERIZED APPROACH FOR CHARACTERIZATION OF LIGAND-BINDING SYSTEMS
MUNSON, PJ
RODBARD, D
[J]. ANALYTICAL BIOCHEMISTRY, 1980, 107 (01) : 220 - 239
[9] RAMSAY LE, 1982, HORMONE ANTAGONISTS, P335

← 1 →