VITAMIN-E-DEFICIENCY HAS A PATHOLOGICAL ROLE IN MYOCYTOLYSIS IN CARDIOMYOPATHIC SYRIAN-HAMSTER (BIO14.6)

被引：10

作者：

SAKANASHI, T ^{[1
]}

SAKO, S ^{[1
]}

NOZUHARA, A ^{[1
]}

ADACHI, K ^{[1
]}

OKAMOTO, T ^{[1
]}

KOGA, Y ^{[1
]}

TOSHIMA, H ^{[1
]}

机构：

[1] KURUME UNIV, INST CARDIOVASC DIS, KURUME, FUKUOKA 830, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 181卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)81393-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study revealed the occurrence of vitamin E deficiency in the myocardium of 60-day-old Syrian cardiomyopathic hamsters (BI014.6), and that this deficiency might be related to the increase in lipid peroxide. Vitamin E administration for ten days effectively restored creatininekinase activity and decreased the lipid peroxide content in the myocardium, returning these to normal control levels (F1b). These results indicate that vitamin E deficiency, possibly combined with oxidative stress in the early cardiomyopathic stage plays an important role in initiating the pathogenesis of myocardial lesions. © 1991 Academic Press, Inc.

引用

页码：145 / 150

页数：6

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