CHARACTERIZATION OF THE THORACIC-DUCT T-HELPER CELLS THAT CO-MEDIATE, WITH ANTIBODY, THE RAPID EXPULSION OF TRICHINELLA-SPIRALIS IN ADULT-RATS

被引：12

作者：

AHMAD, A ^{[1
]}

BELL, RG ^{[1
]}

WANG, CH ^{[1
]}

SACUTO, FR ^{[1
]}

机构：

[1] CORNELL UNIV,NEW YORK STATE COLL VET MED,JAMES A BAKER INST ANIM HLTH,ITHACA,NY 14853

来源：

PARASITE IMMUNOLOGY | 1991年 / 13卷 / 02期

关键词：

TRICHINELLA-SPIRALIS; RAPID EXPULSION; MUSCLE LARVAE; ADOPTIVE TRANSFER; T-HELPER; OX8-OX22-; PASSIVE TRANSFER; IMMUNE SERUM ANTIBODY;

D O I：

10.1111/j.1365-3024.1991.tb00271.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Thoracic duct cells that act synergistically with immune serum or antibody to transfer rapid expulsion of a challenge infection with Trichinella spiralis muscle larvae were characterized as OX38+, OX8-, OX22-T helper cells. Protective capacity was confined to the dividing T helpers that appeared on days 3-5 in the thoracic duct of rats during a T. spiralis infection. To realize their intestinal priming potential in recipient rats, MHC-compatibility between donor and recipient rat was required. Fractionation of immune serum with 40% saturated ammonium sulphate left transferable protective activity in both the precipitate and supernatant fractions. Absorption of immune serum with muscle larvae antigen removed the capacity to transfer protection.

引用

页码：147 / 159

页数：13

共 40 条

[1] SYNERGISTIC INTERACTION BETWEEN IMMUNE SERUM AND THORACIC-DUCT CELLS IN THE ADOPTIVE TRANSFER OF RAPID EXPULSION OF TRICHINELLA-SPIRALIS IN ADULT-RATS [J].

AHMAD, A ;

WANG, CH ;

KORENAGA, M ;

BELL, RG ;

ADAMS, LS .

EXPERIMENTAL PARASITOLOGY, 1990, 71 (01) :90-99

[2] T-CELLS THAT HELP B-CELL RESPONSES TO SOLUBLE-ANTIGEN ARE DISTINGUISHABLE FROM THOSE PRODUCING INTERLEUKIN-2 ON MITOGENIC OR ALLOGENEIC STIMULATION [J].

ARTHUR, RP ;

MASON, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 163 (04) :774-786

[3] CROSS-LINKING OF PROTEINS WITH GLUTARALDEHYDE AND ITS USE FOR PREPARATION OF IMMUNOADSORBENTS [J].

AVRAMEAS, S ;

TERNYNCK, T .

IMMUNOCHEMISTRY, 1969, 6 (01) :53-+

[4] TRICHINELLA-SPIRALIS - EXPRESSION OF RAPID EXPULSION IN RATS EXPOSED TO AN ABBREVIATED ENTERAL INFECTION [J].

BELL, RG ;

MCGREGOR, DD .

EXPERIMENTAL PARASITOLOGY, 1979, 48 (01) :42-50

[5] INTESTINAL MUCUS TRAPPING IN THE RAPID EXPULSION OF TRICHINELLA-SPIRALIS BY RATS - INDUCTION AND EXPRESSION ANALYZED BY QUANTITATIVE WORM RECOVERY [J].

BELL, RG ;

ADAMS, LS ;

OGDEN, RW .

INFECTION AND IMMUNITY, 1984, 45 (01) :267-272

[6]

BELL RG, 1987, IMMUNOLOGY, V61, P221

[7] REQUIREMENT FOR 2 DISCRETE STIMULI FOR INDUCTION OF THE INTESTINAL RAPID EXPULSION RESPONSE AGAINST TRICHINELLA-SPIRALIS IN RATS [J].

BELL, RG ;

MCGREGOR, DD .

INFECTION AND IMMUNITY, 1980, 29 (01) :186-193

[8] TRICHINELLA-SPIRALIS - MEDIATION OF THE INTESTINAL COMPONENT OF PROTECTIVE IMMUNITY IN THE RAT BY MULTIPLE, PHASE-SPECIFIC, ANTI-PARASITIC RESPONSES [J].

BELL, RG ;

MCGREGOR, DD ;

DESPOMMIER, DD .

EXPERIMENTAL PARASITOLOGY, 1979, 47 (02) :140-157

[9] ANTIBODY TO INTERLEUKIN-5 INHIBITS HELMINTH-INDUCED EOSINOPHILIA IN MICE [J].

COFFMAN, RL ;

SEYMOUR, BWP ;

HUDAK, S ;

JACKSON, J ;

RENNICK, D .

SCIENCE, 1989, 245 (4915) :308-310

[10] FUNCTIONAL PROPERTIES OF T AND B CELLS ISOLATED BY AFFINITY CHROMATOGRAPHY FROM RAT THORACIC-DUCT LYMPH [J].

CRUM, ED ;

MCGREGOR, DD .

CELLULAR IMMUNOLOGY, 1976, 23 (02) :211-222

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