INVIVO AND INVITRO TOXICITY OF PHOSPHOLIPASE-C FROM PSEUDOMONAS-AERUGINOSA

被引：34

作者：

MEYERS, DJ

PALMER, KC

BALE, LA

KERNACKI, K

PRESTON, M

BROWN, T

BERK, RS

机构：

[1] WAYNE STATE UNIV,SCH MED,DEPT IMMUNOL MICROBIOL,DETROIT,MI 48201

[2] WAYNE STATE UNIV,SCH MED,DEPT PATHOL,DETROIT,MI 48201

来源：

TOXICON | 1992年 / 30卷 / 02期

关键词：

D O I：

10.1016/0041-0101(92)90469-L

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pseudomonas aeruginosa produces phospholipase C (PLC), a heat-labile hemolysin. Histopathological analysis of PLC-treated mice revealed that the primary target organs involved in PLC-induced toxicity were the liver and kidney. Mice treated i.v. with PLC demonstrated significant tubular epithelial necrosis of the kidney with hematuria, while when given i.p. they exhibited hepatonecrosis with cellular infiltration. Splenomegaly was also a consistent finding. Results from in vitro studies indicate that PLC is toxic for mouse peritoneal cells and human leukocytes.

引用

页码：161 / 169

页数：9

共 12 条

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