SINGLE ELECTRON REDUCTION OF SLOW AND FAST CYTOCHROME-C-OXIDASE

被引:22
作者
MOODY, AJ [1 ]
BRANDT, U [1 ]
RICH, PR [1 ]
机构
[1] DARTMOUTH COLL, HITCHCOCK MED CTR, DARTMOUTH MED SCH, DEPT BIOCHEM, HANOVER, NH 03756 USA
来源
FEBS LETTERS | 1991年 / 293卷 / 1-2期
关键词
CYTOCHROME-C OXIDASE; CYTOCHROME-C; ELECTRON TRANSFER; BINUCLEAR CENTER; PHOTOREDUCTION; BOVINE HEART;
D O I
10.1016/0014-5793(91)81161-Z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Evidence is presented that single electron reduction is sufficient for rapid electron transfer (k > 20 s-1 at pH 8.0 in 0.43 M potassium EDTA) between haem a/Cu(A) and the binuclear centre in 'fast' oxidase, whereas in 'slow' oxidase intramolecular electron transfer is slow even when both Cu(A) and haem a are reduced (k congruent-to 0.01 s-1). However, while a single electron can equilibrate rapidly between Cu(A), haem a and Cu(B) in 'fast' oxidase, it seems that equilibration with haem a3 is relatively slow (k congruent-to 2 s-1). Electron transfer between cytochrome c and Cu(A)/haem a is similar for both types of enzyme (k congruent-to 2.4 x 10(5) M-1.s-1).
引用
收藏
页码:101 / 105
页数:5
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