DETERMINATION OF DISODIUM CLODRONATE IN BULK MATERIAL AND PHARMACEUTICALS BY ION CHROMATOGRAPHY WITH POSTCOLUMN DERIVATIZATION

被引：19

作者：

KOSONEN, JP

机构：

[1] Leiras Oy, Analytical Development, SF-20101 Turku

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1992年 / 10卷 / 10-12期

关键词：

BISPHOSPHONATE; CLODRONATE DISODIUM; ION CHROMATOGRAPHY; PHARMACEUTICAL ANALYSIS;

D O I：

10.1016/0731-7085(91)80095-Q

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A validated ion chromatographic method for the determination of disodium clodronate in bulk material and pharmaceuticals is described. Separations are performed on a poly(styrene-divinylbenzene) copolymer column using 40 mM nitric acid as mobile phase at a flow rate of 0.5 ml min-1. The analyte is detected by UV absorption at 300 nm after post-column derivatization with acidic iron(III) solution (0.25 ml min-1). The proposed ion chromatographic method is validated in terms of selectivity, precision, linearity, accuracy and ruggedness.

引用

页码：881 / 887

页数：7

共 8 条

[1] ANALYSIS OF (DICHLOROMETHYLENE) BISPHOSPHONATE IN URINE BY CAPILLARY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY [J].