ION CHANNELS - MOLECULAR-BASIS OF ION SELECTIVITY

被引：26

作者：

IMOTO, K

机构：

[1] Department of Medical Chemistry, Kyoto University Faculty of Medicine, Kyoto

来源：

FEBS LETTERS | 1993年 / 325卷 / 1-2期

关键词：

ION CHANNEL; ION SELECTIVITY; SITE-DIRECTED MUTAGENESIS; FUNCTIONAL EXPRESSION;

D O I：

10.1016/0014-5793(93)81422-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent mutagenesis studies of the ion channel proteins have allowed us to identify amino acid residues critical in determining ion selectivity. Ion selectivity of a channel can be altered even by single animo acid substitutions. Functional analyses of mutants largely support views in classical biophysics that the pore size and the fixed charges are major determinants of ion selectivity. For full understanding of the molecular mechanism of ion selectivity, elucidation of the tertiary structure of channel proteins remains essential.

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页码：100 / 103

页数：4

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