NEUROTROPHIC EFFECTS OF SUBSTANCE-P ON HIPPOCAMPAL-NEURONS IN-VITRO

被引：30

作者：

WHITTY, CJ

KAPATOS, G

BANNON, MJ

机构：

[1] WAYNE STATE UNIV,SCH MED,DEPT PSYCHIAT,CELLULAR & CLIN NEUROBIOL PROGRAM,DETROIT,MI 48201

[2] WAYNE STATE UNIV,SCH MED,DEPT PHARMACOL,DETROIT,MI 48201

来源：

NEUROSCIENCE LETTERS | 1993年 / 164卷 / 1-2期

关键词：

SUBSTANCE P; ALZHEIMERS DISEASE; NEUROTOXICITY; HIPPOCAMPAL NEURON; NEUROKININ RECEPTOR; CP-96345; TISSUE CULTURE; TACHYKININ; NK-1;

D O I：

10.1016/0304-3940(93)90877-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The potential neurotrophic effect of substance P-like immunoreactivity present in culture media was assessed in rat embryonic day 18 hippocampal cultures. The neurokinin-l (substance P) receptor antagonist CP-96345 induced neurotoxicity that was dose dependent and attenuated by addition of substance P or the neurokinin-1 agonist [Sar(9),Met(O-2)(11)]-SP. These studies suggest that under some conditions neurokinin-l receptor stimulation promotes neuronal survival.

引用

页码：141 / 144

页数：4

共 33 条

[1]

ATTSON MP, 1992, NEUROBIOL AGING, V13, P617

[2] SUBSTANCE-P-LIKE IMMUNOREACTIVITY IS REDUCED IN ALZHEIMERS-DISEASE CEREBRAL-CORTEX [J].