ISOLATION, STRUCTURE, AND SYNTHESIS OF DOLASTATIN-C, A NEW DEPSIPEPTIDE FROM THE SEA HARE DOLABELLA-AURICULARIA

被引：33

作者：

SONE, H ^{[1
]}

NEMOTO, T ^{[1
]}

OJIKA, M ^{[1
]}

YAMADA, K ^{[1
]}

机构：

[1] NAGOYA UNIV,FAC SCI,DEPT CHEM,NAGOYA 464,JAPAN

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 52期

关键词：

D O I：

10.1016/S0040-4039(00)61355-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dolastatin C (1), a new depsipeptide exhibiting weak cytotoxicity, has been isolated from the Japanese sea hare Dolabella auricularia. The structure of 1 was elucidated by spectroscopic analysis and chemical degradation. The synthesis of 1 was carried out to confirm the structure unambiguously.

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页码：8445 / 8448

页数：4

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