FLOW-INJECTION DETERMINATION OF KANAMYCIN BY INHIBITION OF THE LUCIGENIN-H2O2-CO2+ SYSTEM

被引：23

作者：

ALWARTHAN, AA

ALTAMRAH, SA

AKEL, AA

机构：

[1] Chemistry Department, College of Science, King Saud University, Riyadh, 11451

来源：

ANALYTICA CHIMICA ACTA | 1994年 / 292卷 / 1-2期

关键词：

FLOW INJECTION; CHEMILUMINESCENCE; KANAMYCIN; LUCIGENIN SYSTEM; PHARMACEUTICAL PREPARATIONS;

D O I：

10.1016/0003-2670(93)00010-6

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The application of lucigenin chemiluminescence for the determination of trace concentrations of kanamycin is described. The method is based on the inhibiting effect that kanamycin has on the reaction of lucigenin and hydrogen peroxide in a basic solution. The effect of the concentrations of the reagents was studied and the reaction conditions are discussed. The proposed method allows the determination of kanamycin in the range of 1 x 10(-13) to 1 x 10(-5) M with a relative standard deviation of ca. 1.91%. The method is relatively free from the interference of common excipients accompanying the drug in pharmaceutical samples. The results obtained for the assay of commercial preparations compared well with those obtained by another known method and showed good accuracy and precision.

引用

页码：201 / 208

页数：8

共 46 条

[1] DETERMINATION OF MORPHINE BY FLOW-INJECTION ANALYSIS WITH CHEMILUMINESCENCE DETECTION [J].