A SEARCH FOR HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I IN THE LESIONS OF PATIENTS WITH TROPICAL SPASTIC PARAPARESIS AND POLYMYOSITIS

被引：20

作者：

TANGY, F

VERNANT, JC

COSCOY, L

OSSONDO, M

BELLANCE, R

ZANINOVIC, V

CARTIER, L

BRAHIC, M

OZDEN, S

机构：

[1] INST PASTEUR, UNITE VIRUS LENTS, F-75274 PARIS 15, FRANCE

[2] CTR HOSP REG & UNIV FORT FRANCE, SERV NEUROL, FORT DE FRANCE, Martinique, FRANCE

[3] HOSP UNIV VALLE, NEUROL CLIN, CALI, COLOMBIA

[4] UNIV CHILE, SANTIAGO, CHILE

来源：

ANNALS OF NEUROLOGY | 1995年 / 38卷 / 03期

关键词：

D O I：

10.1002/ana.410380317

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We searched for the presence of human T-cell leukemia virus type I (HTLV-I) sequences in central nervous system and muscle lesions of 3 patients with tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM) and 3 patients with HTLV-I-associated polymyositis. Proviral DNA coding for the Tax protein Nas found by polymerase chain reaction amplification in DNA extracted from lesions of every patient with TSP/HAM or HTLV-I-associated polymyositis. In contrast, viral RNA was found occasionally by in situ hybridization in muscle lesions of some patients with polymyositis, but was never found in central nervous system lesions of TSP/HAM patients.

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页码：454 / 460

页数：7

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