Endothelial cell differentiation into capillary structures by copolymer surfaces with phenylboronic acid groups

被引:28
作者
Aoki, T
Nagao, Y
Terada, E
Sanui, K
Ogata, N
Yamada, N
Sakurai, Y
Kataoka, K
Okano, T
机构
[1] TOKYO WOMENS MED COLL,INST BIOMED ENGN,SHINJUKU KU,TOKYO 162,JAPAN
[2] SOPHIA UNIV,FAC SCI & TECHNOL,DEPT CHEM,TOKYO 102,JAPAN
[3] SCI UNIV TOKYO,DEPT MAT SCI,NODA,CHIBA 278,JAPAN
[4] SCI UNIV TOKYO,BIOSCI RES INST,NODA,CHIBA 278,JAPAN
关键词
phenylboronic acid; endothelial cell; capillary structure; glycoconjugates; cell culture;
D O I
10.1163/156856295X00463
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A ternary copolymer composed of m-acrylamidophenylboronic acid, N,N-dimethylaminopropylmethacrylamide and N-isopropylacrylamide was synthesized. Long-term culture of bovine aortic endothelial cells on this copolymer substrate demonstrated adhesion and proliferation of the cells. After 26 days in culture, endothelial cells spontaneously developed into capillary networks. The interactions between phenylboronic acid groups in copolymer and glycoconjugates on endothelial cell plasma membranes are proposed to regulate the induction of tissue formation, since phenylboronic acid groups are known to specifically form reversible complexes with cis-diol compounds such as glucose. This copolymer is a novel material capable of mediating specific signals analogous to extracellular matrix to promote proliferation of endothelial cells, inducing capillary structures and prompt angiogenesis.
引用
收藏
页码:539 / 550
页数:12
相关论文
共 29 条
[1]   TEMPERATURE-DEPENDENCE OF SWELLING OF CROSS-LINKED POLY(N,N'-ALKYL SUBSTITUTED ACRYLAMIDES) IN WATER [J].
BAE, YH ;
OKANO, T ;
KIM, SW .
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 1990, 28 (06) :923-936
[2]   USE OF POLY(4-VINYLBENZENEBORONIC ACID) RESINS IN FRACTIONATION AND INTERCONVERSION OF CARBOHYDRATES [J].
BARKER, SA ;
HATT, BW ;
SOMERS, PJ ;
WOODBURY, RR .
CARBOHYDRATE RESEARCH, 1973, 26 (01) :55-64
[3]   INTERACTION OF ARENEBORONIC ACIDS WITH MONOSACCHARIDES [J].
BARKER, SA ;
CHOPRA, AK ;
HATT, BW ;
SOMERS, PJ .
CARBOHYDRATE RESEARCH, 1973, 26 (01) :33-40
[4]   APPLICATIONS OF IMMOBILIZED PHENYLBORONIC ACIDS AS SUPPORTS FOR GROUP-SPECIFIC LIGANDS IN THE AFFINITY-CHROMATOGRAPHY OF ENZYMES [J].
BOURIOTIS, V ;
GALPIN, IJ ;
DEAN, PDG .
JOURNAL OF CHROMATOGRAPHY, 1981, 210 (02) :267-278
[5]  
FOLKMAN J, 1980, NATURE, V288, P511
[6]   2 DIFFERENT LAMININ DOMAINS MEDIATE THE DIFFERENTIATION OF HUMAN-ENDOTHELIAL CELLS INTO CAPILLARY-LIKE STRUCTURES INVITRO [J].
GRANT, DS ;
TASHIRO, KI ;
SEGULREAL, B ;
YAMADA, Y ;
MARTIN, GR ;
KLEINMAN, HK .
CELL, 1989, 58 (05) :933-943
[7]   MECHANOCHEMICAL SWITCHING BETWEEN GROWTH AND DIFFERENTIATION DURING FIBROBLAST GROWTH FACTOR-STIMULATED ANGIOGENESIS INVITRO - ROLE OF EXTRACELLULAR-MATRIX [J].
INGBER, DE ;
FOLKMAN, J .
JOURNAL OF CELL BIOLOGY, 1989, 109 (01) :317-330
[8]   YIGSR, A SYNTHETIC LAMININ PENTAPEPTIDE, INHIBITS EXPERIMENTAL METASTASIS FORMATION [J].
IWAMOTO, Y ;
ROBEY, FA ;
GRAF, J ;
SASAKI, M ;
KLEINMAN, HK ;
YAMADA, Y ;
MARTIN, GR .
SCIENCE, 1987, 238 (4830) :1132-1134
[9]   ADHESION AND PROLIFERATION OF BOVINE AORTIC ENDOTHELIAL-CELLS ON MONOAMINE-CONTAINING AND DIAMINE-CONTAINING POLYSTYRENE DERIVATIVES [J].
KIKUCHI, A ;
KATAOKA, K ;
TSURUTA, T .
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 1992, 3 (03) :253-260
[10]  
KITANO S, 1991, MAKROMOL CHEM-RAPID, V12, P227