SYNTHESIS OF ALKENE DIPEPTIDE ISOSTERES EMPLOYING THE WITTIG-STILL REARRANGEMENT

被引：19

作者：

BOL, KM ^{[1
]}

LISKAMP, RMJ ^{[1
]}

机构：

[1] LEIDEN UNIV,GORLAEUS LABS,POB 9502,2300 RA LEIDEN,NETHERLANDS

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 39期

关键词：

D O I：

10.1016/S0040-4039(00)92397-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new approach to the synthesis of alkene dipeptide isosteres is reported which features the use of the [2,3]-Wittig-Still rearrangement, carried out in hexane. As an example the synthesis of the alkene dipeptide isostere of Gly-Ala as part of the tripeptide isostere Z-Phe-Gly-PSI[E-CH = CH]-(R, S)Ala-OH is described.

引用

页码：5401 / 5404

页数：4

共 38 条

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