INTERFERON-GAMMA MARKS ACTIVATED LYMPHOCYTES-T IN AIDS PATIENTS

被引：16

作者：

CARUSO, A ^{[1
]}

GONZALES, R ^{[1
]}

STELLINI, R ^{[1
]}

SCALZINI, A ^{[1
]}

PERONI, L ^{[1
]}

TURANO, A ^{[1
]}

机构：

[1] SPEDALI CIVIL BRESCIA,DIV INFECT DIS,BRESCIA,ITALY

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1990年 / 6卷 / 07期

关键词：

D O I：

10.1089/aid.1990.6.899

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lymphocytes expressing interferon-γ (IFN-γ) on their surface were evaluated in 61 patients, all IV drug abusers, infected with human immunodeficiency virus type 1 (HIV-1), and in 85 healthy subjects (61 of whom were blood donors and 24 HIV-1 seronegative IV drug abusers). Data obtained demonstrated that IFN-γ-expressing T lymphocytes, mostly CD8+ cells, were present in HIV-1-infected patients, and that their percentage, always higher in HIV-1-infected patients than in healthy subjects (p ≤ 0.001), increased with progressive stages of HIV-1 infection. At the same time other markers of T-cell activation, namely interleukin-2 receptor (rIL-2), transferrin receptor, and HLA-DR were also found to be positive in some of the HIV-1-infected subjects. The presence in the HIV-1-infected patients of activated CD8+ T cells, which are resistant to HIV-1 infection, may suggest that these cells are able to respond to continuous and progressive viral expression (HIV or/and other viruses) and may be a component of the specific response to HIV-1. © 1990, Mary Ann Liebert, Inc. All rights reserved.

引用

页码：899 / 904

页数：6

共 20 条

[1] EXPRESSION OF GAMMA-INTERFERON ON CIRCULATING LYMPHOCYTES IN VIRAL-INFECTIONS [J].