CENTRAL AND PERIPHERAL BENZODIAZEPINE RECEPTORS - INVOLVEMENT IN AN ORGANISMS RESPONSE TO PHYSICAL AND PSYCHOLOGICAL STRESS

被引：94

作者：

DRUGAN, RC

HOLMES, PV

机构：

[1] Schrier Research Laboratory, Department of Psychology, Brown University, Providence

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 1991年 / 15卷 / 02期

关键词：

CENTRAL BENZODIAZEPINE RECEPTOR; PERIPHERAL BENZODIAZEPINE RECEPTOR; ENVIRONMENTAL STRESS; NEUROCHEMICAL CHANGES;

D O I：

10.1016/S0149-7634(05)80007-7

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The present review discusses the current knowledge of the molecular pharmacology and neuroanatomical and subcellular localization of both the central benzodiazepine/GABA-chloride ionophore receptor complex and the peripheral benzodiazepine receptor. It then reviews all of the literature to date on how these two receptor sites are modulated by environmental stress. The possible role of these sites in learning and memory is also discussed. Finally, a theoretical model is presented which examines the differential, and perhaps complementary, alterations of these two sites in an organism's response to stress.

引用

页码：277 / 298

页数：22

共 328 条

[1] SEDATIVE-HYPNOTIC ANOMALIES RELATED TO DOSE OF PENTOBARBITAL IN LONG-SLEEP AND SHORT-SLEEP SELECTIVELY-BRED MICE [J].