MUCOSAL IMMUNIZATION WITH A LIVE, VIRULENCE-ATTENUATED SIMIAN IMMUNODEFICIENCY VIRUS (SIV) VACCINE ELICITS ANTIVIRAL CYTOTOXIC T-LYMPHOCYTES AND ANTIBODIES IN RHESUS MACAQUES

被引：15

作者：

LOHMAN, BL

MCCHESNEY, MB

MILLER, CJ

OTSYULA, M

BERARDI, CJ

MARTHAS, ML

机构：

[1] UNIV CALIF DAVIS,CALIF REG PRIMATE RES CTR,DAVIS,CA 95616

[2] UNIV CALIF DAVIS,DEPT MED,DAVIS,CA 95616

[3] UNIV CALIF DAVIS,SCH VET MED,DEPT PATHOL MICROBIOL & IMMUNOL,DAVIS,CA 95616

[4] UNIV CALIF DAVIS,SCH MED,DEPT PATHOL,DAVIS,CA 95616

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 1994年 / 23卷 / 2-3期

关键词：

PERIVAGINAL IMMUNIZATION; SIV-SPECIFIC IGG AND IGA ANTIBODIES;

D O I：

10.1111/j.1600-0684.1994.tb00108.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

An effective AIDS vaccine must protect against sexual transmission of human immunodeficiency virus (HIV). Therefore, vaccine regimens which stimulate antiviral immunity in the genital tract as well as in peripheral blood and systemic lymphoid tissues are needed. Here, we describe a method of immunization by direct inoculation of the vaginal submucosa with a live attenuated SIV, SIV(max1A11). Immunization by this route generated low levels of SIV-specific IgG and IgA antibodies in serum and vaginal secretions and viral specific cytotoxic T lymphocyte (CTL) activity in peripheral blood.

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收藏

页码：95 / 101

页数：7

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