SYNTHESIS OF 2,6-DIAMIDOPYRIDINE DERIVATIVES AND THEIR FUNCTIONS AS FLAVIN RECEPTORS IN CHLOROFORM

被引：44

作者：

TAMURA, N ^{[1
]}

MITSUI, K ^{[1
]}

NABESHIMA, T ^{[1
]}

YANO, Y ^{[1
]}

机构：

[1] GUNMA UNIV,DEPT CHEM,KIRYU,GUMMA 376,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 | 1994年 / 10期

关键词：

D O I：

10.1039/p29940002229

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

It has been found that 2,6-diamidopyridine derivatives act as flavin receptors by a triple hydrogen bond towards a uracil moiety of an isoalloxazine ring in CHCl3. The association constants were determined by H-1 NMR (in CDCl3) and fluorescence (in CHCl3) spectroscopies; the largest is ca. 10(3) mol(-1) dm(3). The triple hydrogen bond toward C(2)=0, N(3)-H and C(4)=0 of the isoalloxazine ring was found to enhance slightly the oxidation activity in CHCl3.

引用

页码：2229 / 2237

页数：9

共 45 条

[1] FLAVIN-6-CARBOXYLIC ACIDS AS NOVEL AND SIMPLE FLAVOENZYME MODELS - NONENZYMATIC STABILIZATION OF THE FLAVIN SEMIQUINONE RADICAL AND THE 4A-HYDROPEROXYFLAVIN BY INTRAMOLECULAR HYDROGEN-BONDING [J].