DETECTION OF HUMAN CYTOMEGALOVIRUS GENOME IN UTERUS TISSUE

被引：22

作者：

FURUKAWA, T ^{[1
]}

JISAKI, F ^{[1
]}

SAKAMURO, D ^{[1
]}

TAKEGAMI, T ^{[1
]}

MURAYAMA, T ^{[1
]}

机构：

[1] KANAZAWA MED UNIV, DEPT PATHOL, UCHINADA, ISHIKAWA 92002, JAPAN

来源：

ARCHIVES OF VIROLOGY | 1994年 / 135卷 / 3-4期

关键词：

D O I：

10.1007/BF01310013

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To analyze persistent infection by human cytomegalovirus (HCMV) in vivo, specimens obtained from various sources and autopsied organs were examined for the presence of HCMV DNA, mRNA transcripts and antigens by polymerase chain reaction, in situ hybridization and immunostaining. The HCMV genome was detected in lung, liver, kidney, and blood vessels at an average positive rate of 15%. The highest PCR-positive rate was observed with cervical smears. Subsequent examination of uterus tissues from patients with myoma revealed HCMV transcripts and antigens in glandular epithelial cells, leukocytes, endothelial cells, and others, indicating productive HCMV infection of cervical tissue.

引用

页码：265 / 277

页数：13

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