AN ENANTIOSPECIFIC SYNTHESIS OF ALLOSAMIZOLINE

被引：38

作者：

SIMPKINS, NS ^{[1
]}

STOKES, S ^{[1
]}

WHITTLE, AJ ^{[1
]}

机构：

[1] ICI AGROCHEM,JEALOTTS HILL RES STN,BRACKNELL RG12 6EY,BERKS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 19期

关键词：

D O I：

10.1039/p19920002471

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantiospecific synthesis of allosamizoline 4, the aglycone of the chitinase inhibitor allosamidin 3, has been achieved, starting from readily available glucosamine. The key step in the synthesis involves the cyclisation of a carbon-centred radical onto a suitably positioned oxime ether group, thus effectively converting a carbohydrate derivative into a highly functionalised cyclopentane.

引用

页码：2471 / 2477

页数：7

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