THE PROTECTIVE ROLE OF GALLIC ACID-ESTERS IN BACTERIAL CYTOTOXICITY AND SOS RESPONSES INDUCED BY HYDROGEN-PEROXIDE

被引：31

作者：

NAKAYAMA, T ^{[1
]}

HIRAMITSU, M ^{[1
]}

OSAWA, T ^{[1
]}

KAWAKISHI, S ^{[1
]}

机构：

[1] NAGOYA UNIV, DEPT FOOD SCI & TECHNOL CHIKUSA KU, NAGOYA 46401, JAPAN

来源：

MUTATION RESEARCH | 1993年 / 303卷 / 01期

关键词：

HYDROGEN PEROXIDE; GALLIC ACID ESTERS; POLYPHENOL; SALMONELLA-TYPHIMURIUM TA104; ESCHERICHIA-COLI PQ37; SOS RESPONSE;

D O I：

10.1016/0165-7992(93)90005-G

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The effects of gallic acid and its esters on H2O2-induced cytotoxicity, mutagenicity and SOS response were investigated in bacterial assay systems, i.e., the Ames test with Salmonella typhimurium TA104 and the SOS chromotest with E. coli PQ37. In the Ames test, gallic acid esters showed protective effects against H2O2-induced cytotoxicity and no effects on the number of revertant colonies. In the SOS chromotest, gallic acid esters lowered the SOS induction factor raised by H2O2. Throughout the study, the effects of gallic acid itself were weak or negligible, and lauryl gallate was most effective among the three gallic acid esters. This structure-activity relationship indicates the similarity of the protective effects of gallic acid esters on the H2O2-induced damages to both bacterial and mammalian cells.

引用

页码：29 / 34

页数：6

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