MODIFICATIONS OF GLIAL METABOLISM OF GLUTAMATE AFTER SEROTONERGIC NEURON DEGENERATION IN THE HIPPOCAMPUS OF THE RAT

被引：14

作者：

HARDIN, H ^{[1
]}

BERNARD, A ^{[1
]}

RAJAS, F ^{[1
]}

FEVREMONTANGE, M ^{[1
]}

DERRINGTON, E ^{[1
]}

BELIN, MF ^{[1
]}

DIDIERBAZES, M ^{[1
]}

机构：

[1] FAC MED ALEXIS CARREL,INSERM,U369,F-69372 LYON 08,FRANCE

来源：

MOLECULAR BRAIN RESEARCH | 1994年 / 26卷 / 1-2期

关键词：

ASTROCYTE; GLUTAMATE DEHYDROGENASE; GLUTAMATE METABOLISM; GLUTAMINE SYNTHETASE; HIPPOCAMPUS; SEROTONIN; NEURON-GLIA INTERACTION;

D O I：

10.1016/0169-328X(94)90067-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have investigated the role of serotonergic neurons on the astrocytes catabolism of glutamate by analyzing glutamine synthetase (GS) and glutamate dehydrogenase (GDH) expression in the hippocampus after the degeneration of serotonergic neurons by a specific neurotoxin (5,7-DHT). 5,7-DHT caused reactive gliosis with hypertrophy (increase in glial fibrillary acidic protein (GFAP) expression) but not proliferation of astrocytes. Glutamate metabolism appeared preferentially regulated by a control of GDH expression rather than GS since the expression of GDH was specifically and significantly induced in the hippocampus whereas the level of GS remained unchanged. The inhibition of serotonin synthesis (by para -chlorophenylalanine (p-CPA) administration) produced no significant increase of GDH level. This suggests that serotonin is not the principal factor involved in this control of GDH expression.

引用

页码：1 / 8

页数：8

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