SULFATIDE, A SPECIFIC SUGAR LIGAND FOR L-SELECTIN, BLOCKS CCL4-INDUCED LIVER INFLAMMATION IN RATS

被引：19

作者：

KAJIHARA, JI ^{[1
]}

GUOJI, Y ^{[1
]}

KATO, K ^{[1
]}

SUZUKI, Y ^{[1
]}

机构：

[1] UNIV SHIZUOKA, SCH PHARMACEUT SCI, DEPT BIOCHEM, SHIZUOKA 422, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1995年 / 59卷 / 01期

关键词：

D O I：

10.1271/bbb.59.155

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of sulfatide, which is a specific sugar ligand for L-selectin (LECAM-1), on CCl4-induced liver inflammation was studied in rats. Intramuscular pretreatment with sulfatide suppressed the levels of serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) that were increased by CCl4 injection, but galactosylceramide, a desulfated form of sulfatide, did not. A light-microscopic analysis found that the extent and the severity of lesions of the liver cells induced by CCl4 injection were significantly less in the rats treated with sulfatide. These results show that sulfatide suppresses the CCl4-induced liver inflammation by inhibiting tile attachment of L-selectin expressing lymphocytes to their native sugar ligands.

引用

页码：155 / 157

页数：3

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