THE RHINO MOUSE MODEL - THE EFFECTS OF TOPICALLY APPLIED ALL-TRANS-RETINOIC ACID AND CD271 ON THE FINE-STRUCTURE OF THE EPIDERMIS AND UTRICLE WALL OF PSEUDOCOMEDONES

被引:31
作者
BERNERD, F [1 ]
ORTONNE, JP [1 ]
BOUCLIER, M [1 ]
CHATELUS, A [1 ]
HENSBY, C [1 ]
机构
[1] HOP LOUIS PASTEUR, DEPT DERMATOL, F-06000 NICE, FRANCE
关键词
RHINO MOUSE SKIN; ALL-TRANS-RETINOIC ACID; CD271; ULTRASTRUCTURE;
D O I
10.1007/BF00371617
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The histological and ultrastructural effects following 3 weeks' topical treatment with two agents (all-trans retinoic acid and a new synthetic retinoid-like substance, CD271) were evaluated on the epidermis and the epithelial wall of the pseudocomedones in rhino mouse skin. The comedolytic effects of these drugs were similar, and consisted of a reduction of the utricular diameter, with normalization of follicular units. Morphological examinations revealed a hyperplastic response with an increase in the number of cell layers of both epidermis and follicular epithelium, and modifications in keratinocyte differentiation. Ultrastructural changes in the epidermis and epithelial wall were observed mainly in the granular and horny layers, with increased desquamation, and a decrease in the cohesiveness of corneocytes. During the first week of treatment, some cutaneous toxic effects were noticed, but they normalized within two weeks. On the other hand, a fine granular material persisted in the intercellular spaces. It is confirmed that the skin of the rhino mouse is a good model for the evaluation of the comedolytic effects of drugs. Moreover, it reveals the specific effects of retinoids on epidermal differentiation. We have demonstrated that topically applied CD271 induces modifications similar to those obtained with all-trans retinoic acid. It is thus concluded that CD271 is a potentially effective anti-acne agent.
引用
收藏
页码:100 / 107
页数:8
相关论文
共 27 条
[1]   HISTOLOGIC-CHANGES IN THE SKIN OF THE RHINO MOUSE (HRRHHRRH) INDUCED BY RETINOIDS [J].
ASHTON, RE ;
CONNOR, MJ ;
LOWE, NJ .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1984, 82 (06) :632-635
[2]  
BERNERD F, 1989, PHARM SKIN PHARM RET, P139
[3]   A NEW MODEL FOR THE ASSAY OF COMEDOLYTIC ACTIVITY [J].
BONNE, C ;
ZEZIOLA, F ;
SECCHI, J ;
SAURAT, JH .
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, 1981, 3 (01) :23-28
[4]  
BOUCLIER M, 1989, PHARM SKIN PHARM RET, P136
[5]   COMPARATIVE ULTRASTRUCTURE AND CYTOCHEMISTRY OF EPIDERMAL RESPONSES TO TAPE STRIPPING, ETHANOL AND VITAMIN-A ACID IN HAIRLESS MICE [J].
BROWN, WR ;
HABOWSKY, JEJ .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1979, 73 (03) :203-206
[6]  
CHATELUS A, 1989, PHARM SKIN PHARM RET, P144
[7]   STIMULATION OF EPIDERMAL DNA-SYNTHESIS BY VITAMIN A-ACID [J].
CHRISTOPHERS, E ;
BRAUNFAL.O .
ARCHIV FUR KLINISCHE UND EXPERIMENTELLE DERMATOLOGIE, 1968, 232 (04) :427-+
[8]   RHINO MUTANT MOUSE AS AN EXPERIMENTAL TOOL [J].
DAVIES, RE ;
AUSTIN, WA ;
LOGANI, MK .
TRANSACTIONS OF THE NEW YORK ACADEMY OF SCIENCES, 1971, 33 (07) :680-&