POSTOPERATIVE COURSE OF PLASMA-PROTEIN BINDING OF LIGNOCAINE, ROPIVACAINE AND BUPIVACAINE IN SHEEP

被引：13

作者：

RUTTEN, AJ ^{[1
]}

MATHER, LE ^{[1
]}

PLUMMER, JL ^{[1
]}

HENNING, EC ^{[1
]}

机构：

[1] UNIV SYDNEY,ROYAL N SHORE HOSP,DEPT ANAESTHESIA & PAIN MANAGEMENT,ST LEONARDS,NSW 2065,AUSTRALIA

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1992年 / 44卷 / 04期

关键词：

D O I：

10.1111/j.2042-7158.1992.tb03620.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The plasma protein binding of the 2,6-xylidide local anaesthetic agents lignocaine, ropivacaine and bupivacaine enantiomers was determined by equilibrium dialysis in plasma obtained from chronically catheterized sheep before and up to 21 days after surgery. Three concentrations (1, 5 and 10 mg L-1), were used for each agent. Concentration-dependent binding was evident for each agent throughout the study period. R(+)-Bupivacaine was more extensively bound than S(-)-bupivacaine at the higher concentrations. Compared with pre-surgery, binding of each agent was less on the first postoperative day but did not differ significantly from days 8 to 21.

引用

页码：355 / 358

页数：4

共 25 条

[1] SEQUENTIAL CHANGES OF PLASMA-PROTEINS AFTER SURGICAL TRAUMA [J].