OSTEOCONDUCTION EXERTED BY METHYLPYRROLIDINONE CHITOSAN USED IN DENTAL SURGERY

被引：132

作者：

MUZZARELLI, RAA ^{[1
]}

BIAGINI, G ^{[1
]}

BELLARDINI, M ^{[1
]}

SIMONELLI, L ^{[1
]}

CASTALDINI, C ^{[1
]}

FRATTO, G ^{[1
]}

机构：

[1] UNIV BOLOGNA,FAC MED,I-40100 BOLOGNA,ITALY

来源：

BIOMATERIALS | 1993年 / 14卷 / 01期

关键词：

DENTAL MATERIALS; CHITOSAN; BONE REGENERATION;

D O I：

10.1016/0142-9612(93)90073-B

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Surgical wounds from wisdom tooth avulsions were medicated with freeze-dried methylpyrrolidinone chitosan, a gel-forming resorbable biopolymer obtained from crab chitosan by chemical modification. Methylpyrrolidinone chitosan promoted osteoconduction and the space left after avulsion was filled with newly formed bone tissue, which conferred desirable mechanical and physiological characteristics to the healed wound site. Morphological evidence obtained from biopsies confirmed the radiographic data. Methylpyrrolidinone chitosan was progressively depolymerized by lysozyme and was no longer detected 6 months after surgery. None of the 10 patients reported adverse effects over one year of observation.

引用

页码：39 / 43

页数：5

共 23 条

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