Adducts of organotin(IV), tin(IV) and tin(II) halides with 1-methyl-imidazoline-2(3H)-thione (Hmimt) and imidazoline-2(1,3H)-thione (Himt). Synthesis, spectroscopic (IR, Mossbauer and H-1, C-13, Sn-119 NMR) studies and in vitro antitumour activity

The reactions of 1-methyl-imidazoline-2(3H)-thione (Hmimt) and imidazoline-2(1,3H) -thione (Himt) with organotin(IV), tin(IV) and tin(lI) halides were studied. Ten novel adducts were prepared and characterised by elemental analysis, conductivity measurements, IR, far-IR, H-1 NMR, C-13 NMR,Sn-119 NMR and Mossbauer spectroscopy. The ligands behave as monodentate and exhibit sulfur coordination. The structure of the complexes, in the solid state, is discussed in terms of the Mossbauer quadrupole splitting and the tin-ligand stretching vibrations in the IR and far-IR spectra. The behaviour of the adducts upon dissolution to D2O and CDCl3 is also discussed. Octahedral dimeric and monomeric stereochemistries are assigned for organotin(IV) and tin(IV) adducts in the solid state. The in vitro antitumour activity against six human cell lines, MCF-7, EVSA (two breast cancers), WiDr (a colon cancer), IGROV (an ovarian cancer), M19MEL (a melanoma) and A498 (a renal cancer) for the adducts [SnBuCl(3)(Hmimt)](2), [SnMeCl(3)(Himt)](2) and SnMe(2)Cl(2)(Himt)(2) is reported.