EFFECT OF NAFOXIDINE (U-11,100A) ON INDUCTION OF UTERINE PEROXIDASE

被引：16

作者：

MCNABB, T ^{[1
]}

JELLINCK, PH ^{[1
]}

机构：

[1] QUEENS UNIV, DEPT BIOCHEM, KINGSTON, ONTARIO, CANADA

来源：

STEROIDS | 1976年 / 27卷 / 05期

关键词：

D O I：

10.1016/S0039-128X(76)90208-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relationship between the quantity of nuclear estrogen receptor complex formed and the amount of peroxidase induced by estradiol in immature rat uteri was determined. A good correlation was obtained between the quantity of 3H-estradiol specifically bound to the nuclear pellet and the amount of enzyme present 12 h after treatment with physiological doses of estrogen. Nafoxidine (U-11,100A) administered together with estrogen reduced significantly the increase in peroxidase activity brought about by estradiol. Pretreatment with nafoxidine was less effective. The possible mechanism of action of this antiestrogen is discussed.

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页码：681 / 689

页数：9

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