METHOD SPECIFIC FOR DETERMINATION OF FURAZOLIDONE IN URINE - EVIDENCE FOR DRUG-RELATED METABOLITES

被引：14

作者：

HOLLIFIELD, RD

CONKLIN, JD

机构：

[1] Physiology Section, Eaton Laboratories, The Norwich Pharmacal Co, Norwich, New York

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1968年 / 57卷 / 02期

关键词：

Colorimetry—analysis; Furazolidone; Metabolites; furazolidone—analysis in urine; Paper chromatography—analysis; Urine—furazolidone analysis procedure;

D O I：

10.1002/jps.2600570220

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Furazolidone, N‐(5‐nitro‐2‐furfurylidene)‐3‐amino‐2‐oxazolidinone, is a chemotherapeutic drug used orally for the treatment of bacterial enteritis. A new, more specific analytical method for the determination of furazolidone in urine is described. Utilizing this procedure, furazolidone was not detected in urine samples collected from dogs and humans following oral administration of the drug. Evidence is provided for the presence of drug‐related metabolites. Copyright © 1968 Wiley‐Liss, Inc., A Wiley Company

引用

页码：325 / +

页数：1

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