EPIDERMAL GROWTH-FACTOR RECEPTOR EXPRESSION IN DEMENTED AND AGED HUMAN BRAIN

被引：31

作者：

STYREN, SD

MUFSON, EJ

STYREN, GC

CIVIN, WH

ROGERS, J

机构：

[1] INST BIOGERONTOL RES,LJ ROBERTS CTR,POB 1278,SUN CITY,AZ 85372

[2] ARIZONA STATE UNIV,DEPT ZOOL,TEMPE,AZ 85287

来源：

BRAIN RESEARCH | 1990年 / 512卷 / 02期

关键词：

Alzheimer's disease; Endothelial cell; Epidermal growth factor; Epidermal growth factor receptor; Parkinson's disease;

D O I：

10.1016/0006-8993(90)90647-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Immunoreactivity to epidermal growth factor receptor (EGFR) was present in the brain vasculature of13/13 demented elderly patients, but absent in9/11 non-demented elderly patients. Of the two positive non-demented patients, one had significant Alzheimer's pathology and the other spinal carcinoma. Ultrastructurally, EGFR is localized to the lumenal surface of endothelial cells. © 1990 Elsevier Science Publishers B. V. (Biomedical Division).

引用

页码：347 / 352

页数：6

共 41 条

[1] IMMUNOREACTIVE EPIDERMAL GROWTH-FACTOR RECEPTORS IN NEURITIC PLAQUES FROM PATIENTS WITH ALZHEIMERS-DISEASE [J].