GENISTEIN, A SELECTIVE PROTEIN TYROSINE KINASE INHIBITOR, INHIBITS INTERLEUKIN-2 AND LEUKOTRIENE-B4 PRODUCTION FROM HUMAN MONONUCLEAR-CELLS

被引：33

作者：

ATLURU, D

JACKSON, TM

ATLURU, S

机构：

[1] UNIV MICHIGAN,MED CTR,MICHIGAN DIABET RES & TRAINING CTR,ANN ARBOR,MI 48109

[2] UNIV MINNESOTA,DEPT FAMILY PRACTICE,MINNEAPOLIS,MN 55455

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1991年 / 59卷 / 03期

关键词：

D O I：

10.1016/0090-1229(91)90033-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, genistein, a selective protein tyrosine kinase (PTK) inhibitor, inhibited peripheral blood mononuclear cell (PBMC) proliferation and interleukin-2 production from cultures that were stimulated with phytohemagglutinin (PHA), phorbol 12-myristate 13-acetate (PMA) plus A23187, or PHA plus PMA, and genistein effectively blocked the PHA plus IL-2-induced PBMC proliferation. Further, we also found that genistein inhibited LTB4 production from A23187-stimulated cultures whereas H-7, a PKC inhibitor, had no effect on LTB4 production. Our results suggest that PTK may be necessary for the synthesis of LTB4. © 1991.

引用

页码：379 / 387

页数：9

共 43 条

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