THE EFFECT OF DECREASING THE CONCENTRATION OF URINARY URATE ON THE CRYSTALLIZATION OF CALCIUM-OXALATE IN UNDILUTED HUMAN URINE

被引：8

作者：

GROVER, PK

RYALL, RL

POTEZNY, N

MARSHALL, VR

机构：

[1] FLINDERS UNIV,MED CTR,UROL UNIT,BEDFORD PK,SA 5042,AUSTRALIA

[2] INST MED & VET SCI,DIV CLIN CHEM,ADELAIDE,SA 5000,AUSTRALIA

来源：

JOURNAL OF UROLOGY | 1990年 / 143卷 / 05期

关键词：

D O I：

10.1016/S0022-5347(17)40183-2

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of lowering the urate concentration, using uricase immobilized on to nylon tubing, on the nucleation, growth and aggregation of calcium oxalate crystals in undiluted human urine was examined. The median urate concentration was significantly (P < 0.01) reduced from 2.8 to 0.55 mmol/l., but this had no reproducible effect on the metastable limits, the volume of crystalline calcium oxalate deposited and the size of the crystals and aggregates produced from the 10 urine samples examined. It was concluded that further studies aimed at testing the effects of a raised urinary urate concentration on the crystallization of calcium oxalate should be made a matter of high priority.

引用

页码：1057 / 1061

页数：5

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