FREQUENT ISOLATION OF INTERTYPIC POLIOVIRUS RECOMBINANTS WITH SEROTYPE-2 SPECIFICITY FROM VACCINE-ASSOCIATED POLIO CASES

被引:81
作者
LIPSKAYA, GY
MUZYCHENKO, AR
KUTITOVA, OK
MASLOVA, SV
EQUESTRE, M
DROZDOV, SG
BERCOFF, RP
AGOL, VI
机构
[1] ACAD SCI USSR,INST POLIOMYELITIS & VIRAL ENCEPHALITIDES,MOSCOW 142782,USSR
[2] MV LOMONOSOV STATE UNIV,AN BELOZERSKY MOLEC BIOL & BIOORGAN CHEM LAB,MOSCOW 117234,USSR
[3] INST SUPER SANITA,VIROL LAB,ROME,ITALY
[4] UNIV ROME,INST VIROL,I-00185 ROME,ITALY
关键词
VACCINE-ASSOCIATED POLIOMYELITIS; POLIOVIRUS RECOMBINANTS; SEROTYPE-2; SPECIFICITY;
D O I
10.1002/jmv.1890350415
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Five representatives from a collection of 21 Sabin type 2-like poliovirus strains isolated from paralytic poliomyelitis cases in two regions of the USSR have been subjected to limited nucleotide sequencing. All proved to be intertypic recombinants having the genes encoding capsid proteins of Sabin 2 origin and a 3'-end portion of the genome derived from either type 1 (3 isolates) or type 3 (2 isolates) Sabin strains. The crossover points in all the 5 genomes have been mapped to different loci of the P3 region. At least 6 additional isolates from the same collection (and 2 isolates from healthy contacts), appeared to have a type 2/type 1 recombinant genome, as judged by oligonucleotide mapping. The biological significance of frequent occurrence of recombinants among field isolates of vaccine-related strains is discussed.
引用
收藏
页码:290 / 296
页数:7
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