APOLIPOPROTEIN-B IMMUNOREACTIVITY IN SENILE PLAQUE AND VASCULAR AMYLOIDS AND NEUROFIBRILLARY TANGLES IN THE BRAINS OF PATIENTS WITH ALZHEIMERS-DISEASE

被引：61

作者：

NAMBA, Y ^{[1
]}

TSUCHIYA, H ^{[1
]}

IKEDA, K ^{[1
]}

机构：

[1] TOKYO INST PSYCHIAT,DEPT ULTRASTRUCT & HISTOCHEM,TOKYO,JAPAN

来源：

NEUROSCIENCE LETTERS | 1992年 / 134卷 / 02期

关键词：

APOLIPOPROTEIN-B; ALZHEIMERS DISEASE; AMYLOID; NEUROFIBRILLARY TANGLE; IMMUNOHISTOCHEMISTRY; PHOSPHORYLATION;

D O I：

10.1016/0304-3940(92)90531-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Based upon our previous finding of the association of apolipoprotein E (apoE) immunoreactivity with cerebral amyloids and neurofibrillary tangles (NFTs), we examined immunohistochemically whether this is also the case for apolipoprotein B (apoB). Polyclonal antibody to apoB immunostained senile plaque amyloid, vascular amyloid, subpial amyloid deposits and intracellular NFTs in formalin-fixed, paraffin-embedded brain sections from patients with Alzheimer disease. Hydrated autoclave pretreatment of the sections enhanced the staining of plaque amyloid. The results may suggest a role of apoB in amyloid and NFT formation.

引用

页码：264 / 266

页数：3

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