A NOVEL POLYLOCUS METHOD FOR LINKAGE ANALYSIS USING THE LOD-SCORE OR AFFECTED SIB-PAIR METHOD

被引：34

作者：

TERWILLIGER, JD

OTT, J

机构：

[1] Department of Genetics and Development, Columbia University, New York

来源：

GENETIC EPIDEMIOLOGY | 1993年 / 10卷 / 06期

关键词：

POLYLOCUS LINKAGE ANALYSIS; AFFECTED SIB-PAIR ANALYSIS; MARKER;

D O I：

10.1002/gepi.1370100625

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A novel approach to combining data from multiple linked loci is proposed that can provide substantial increases in power over normal two-point linkage analysis or sib-pair analysis, with a substantial saving in computing time over traditional multipoint methods. (C) 1993 Wiley-Liss, Inc.

引用

页码：477 / 482

页数：6

共 7 条

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[6] ON THE RELATIVE IMPORTANCE OF MARKER HETEROZYGOSITY AND INTERMARKER DISTANCE IN GENE-MAPPING
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[J]. GENOMICS, 1992, 13 (04) : 951 - 956
[7] Terwilliger Joseph D., 1992, American Journal of Human Genetics, V51, pA202

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