RELATIONSHIP OF PLASMINOGEN-ACTIVATOR INHIBITOR-1 WITH PLASMA-INSULIN, GLUCOSE, TRIGLYCERIDE AND CHOLESTEROL IN CHINESE PATIENTS WITH DIABETES

Plasminogen activator inhibitor-1 (PAI) activity, plasma insulin, glucose, cholesterol and triglyceride (TG) concentrations were determined in 32 Chinese diabetic patients (mean age 61.4 yr) and 41 healthy controls (mean age 64.5 yr) to establish the relationships between these parameters. Insulin, glucose, cholesterol and triglyceride levels were significantly higher in the diabetics, whereas no significant difference of PAI activity was noted between groups. PAI activity was not affected by the increase of plasma insulin, cholesterol, TG or glucose. We have shown that PAI activity in Chinese diabetics was not affected by the common pathologic changes found in diabetes. This might be one of the reasons why fibrinolytic activity is not impaired in Chinese diabetics.